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Bite-Sized Biochemistry #37 – Fatty Acid Metabolism II

(01/31/11) Lecture by Kevin Ahern of Oregon State University discussing Biochemistry Basics in BB 451. See the full course at oregonstate.edu This course can be taken for credit (wherever you live) via OSU's ecampus. For details, see ecampus.oregonstate.edu Download Metabolic Melodies at www.davincipress.com Related courses include BB 350 - oregonstate.edu BB 450 - oregonstate.edu BB 100 - oregonstate.edu 1. Oxidation of biologically occurring fatty acids with cis double bonds requires two additional enzymes compared to oxidation of saturated fatty acids. These enzymes are enoyl-CoA-isomerase and 2,4-dienoyl-CoA-reductase. 2. Enoyl-CoA-isomerase (also known as Cletus) converts cis or trans bonds between carbons 3 and 4 to trans bonds between carbons 2 and 3. Since beta oxidation normally has trans bonded intermediates between carbons 2 and 3, this enzyme is sufficient for conversion of many naturally occurring fatty acids to be oxidized. 3. 2,4-dienoyl-CoA reductase (also known as Wallace) acts on intermediates that have double bonds between carbons 2-3 and 4-5. It uses NADPH to reduce the two double bonds to one double bond and the resulting double bond is placed in a cis configuration between carbons 3-4. Enoyl-CoA-isomerase then can convert this intermediate to one with a trans double bond between carbons 2-3, thus allowing beta oxidation to continue. 4. Oxidation of fatty acids with odd numbers of carbons yields a final product of propionyl-CoA, not acetyl-CoA ...